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Ron Firestein Selected Research

monomethyl auristatin E

1/2017Preclinical Efficacy of an Antibody-Drug Conjugate Targeting Mesothelin Correlates with Quantitative 89Zr-ImmunoPET.
5/2016ImmunoPET helps predicting the efficacy of antibody-drug conjugates targeting TENB2 and STEAP1.
11/2015Preclinical Development of an Anti-NaPi2b (SLC34A2) Antibody-Drug Conjugate as a Therapeutic for Non-Small Cell Lung and Ovarian Cancers.
11/2014An antimesothelin-monomethyl auristatin e conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models.
3/2011An antibody-drug conjugate targeting the endothelin B receptor for the treatment of melanoma.

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Ron Firestein Research Topics

Disease

31Neoplasms (Cancer)
01/2022 - 06/2007
9Colorectal Neoplasms (Colorectal Cancer)
01/2021 - 09/2008
8Colonic Neoplasms (Colon Cancer)
02/2016 - 04/2008
7Breast Neoplasms (Breast Cancer)
11/2019 - 06/2007
4Melanoma (Melanoma, Malignant)
12/2015 - 03/2011
3Ovarian Neoplasms (Ovarian Cancer)
01/2017 - 07/2015
2Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)
01/2020 - 04/2015
2Mesothelioma
01/2017 - 11/2014
2Prostatic Neoplasms (Prostate Cancer)
05/2016 - 01/2013
2Microsatellite Instability
06/2010 - 07/2009
2Carcinogenesis
09/2008 - 04/2008
1Liver Neoplasms (Liver Cancer)
01/2021
1Tics (Tic)
03/2017
1Pancreatic Neoplasms (Pancreatic Cancer)
01/2017
1Carcinoma (Carcinomatosis)
07/2015
1Ovarian Epithelial Carcinoma
07/2015
1Stomach Neoplasms (Stomach Cancer)
05/2014
1Disease Progression
05/2013
1Adenocarcinoma of Lung
02/2013
1Triple Negative Breast Neoplasms
11/2012
1Obesity
07/2009

Drug/Important Bio-Agent (IBA)

12Immunoconjugates (Immunoconjugate)IBA
11/2019 - 03/2011
6beta CateninIBA
06/2010 - 04/2008
5Proteins (Proteins, Gene)FDA Link
01/2018 - 07/2012
5monomethyl auristatin EIBA
01/2017 - 03/2011
4Phosphotransferases (Kinase)IBA
01/2022 - 06/2007
4CateninsIBA
01/2021 - 05/2013
4AntibodiesIBA
01/2018 - 03/2011
3Pharmaceutical PreparationsIBA
01/2018 - 07/2015
3Monoclonal AntibodiesIBA
03/2017 - 03/2011
3Small Interfering RNA (siRNA)IBA
10/2016 - 03/2011
2Hormones (Hormone)IBA
11/2019 - 01/2018
2Glial Cell Line-Derived Neurotrophic Factor ReceptorsIBA
11/2019 - 01/2018
2Phenobarbital (Luminal)FDA Link
01/2018 - 11/2012
2AntigensIBA
03/2017 - 07/2015
2MesothelinIBA
01/2017 - 11/2014
2Biomarkers (Surrogate Marker)IBA
06/2015 - 04/2015
2lactate dehydrogenase 1 (LDH1)IBA
02/2013 - 11/2012
2Cyclin-Dependent Kinases (cdk Proteins)IBA
04/2012 - 06/2010
2Fatty Acid Synthases (Fatty Acid Synthase)IBA
06/2010 - 07/2009
2Mediator ComplexIBA
06/2010 - 09/2008
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
06/2010 - 07/2009
2Sirtuin 1IBA
07/2009 - 04/2008
1DiamondIBA
01/2021
1formycin diphosphate (FDP)IBA
01/2021
1Doxorubicin (Adriamycin)FDA LinkGeneric
01/2021
1Calcibiotic Root Canal SealerIBA
01/2021
1Ligases (Synthetase)IBA
01/2018
1CitrullineIBA
01/2018
1Valine (L-Valine)FDA Link
01/2018
1EnzymesIBA
01/2018
1gamma-glutamylcysteineIBA
01/2018
1Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
01/2018
1Glutathione (Reduced Glutathione)IBA
01/2018
1GlutaminaseIBA
01/2018
1Biological ProductsIBA
03/2017
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
10/2016
1GNE-140IBA
10/2016
1RNA (Ribonucleic Acid)IBA
02/2016
1Long Noncoding RNAIBA
02/2016
1Oncogene Proteins (Oncogene Protein)IBA
12/2015
1Sodium-Phosphate Cotransporter Proteins (Sodium-Phosphate Cotransporter)IBA
11/2015
1PeriostinIBA
07/2015
1PlatinumIBA
07/2015
1Glycogen Synthase KinasesIBA
04/2015
1Casein Kinases (Casein Kinase)IBA
04/2015
1Immunotoxins (Immunotoxin)IBA
11/2014
1RibonucleoproteinsIBA
05/2014
1Small Nuclear Ribonucleoproteins (snRNP)IBA
05/2014
1Protein Isoforms (Isoforms)IBA
05/2014
1Transcription Factors (Transcription Factor)IBA
05/2014
1G244-LMIBA
05/2013
1G007-LKIBA
05/2013
1Axin ProteinIBA
05/2013
1TankyrasesIBA
05/2013
1Tyrosine (L-Tyrosine)FDA Link
05/2013
1ErbB Receptors (EGF Receptor)IBA
05/2013
1AndrogensIBA
01/2013
1Progesterone Receptors (Progesterone Receptor)IBA
11/2012
1Estrogens (Estrogen)FDA Link
11/2012
1Lactic Acid (Lactate)FDA LinkGeneric
11/2012
1Endothelin B ReceptorIBA
03/2011
1Messenger RNA (mRNA)IBA
03/2011
1Membrane Proteins (Integral Membrane Proteins)IBA
03/2011
1Cyclin D1IBA
06/2010
1Casein Kinase 1 epsilonIBA
02/2010
1Histone Deacetylases (Histone Deacetylase)IBA
07/2009
1SirtuinsIBA
07/2009
1NAD (NADH)IBA
04/2008
1NF-kappa B (NF-kB)IBA
06/2007
1I-kappa B KinaseIBA
06/2007

Therapy/Procedure

10Therapeutics
01/2021 - 04/2008
2Drug Therapy (Chemotherapy)
07/2015 - 07/2015
1Castration
05/2016